Figure 5
Normal acquisition and retention of conditioned taste aversion in BRI2-Aβ mice. Experimentally experienced mice (Figures 3 and 4A-C) were tested at the age of 15.8 months. All genotypes showed strong and resistant to extinction memory of the association between the taste of saccharine and gastric nausea. Conditioned taste aversion was not impaired by selective expression of Aβ1-40 or Aβ1-42 in the brain. (A) Saccharine intake in two-choice test carried out on D2 after CS-US pairing. (B) Strong and resistant to extinction saccharine avoidance in the series of retention tests carried out between D10 and D15 after CS-US pairing. (C) Control (saline injected) unconditioned mice showed strong and stable preference for saccharine. The dashed line (panels A and B) represents a chance level performance. Error bars represent s.e.m. * p < 0.001 indicates the comparison of each genotype against 50% chance level performance.