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Figure 2 | Molecular Neurodegeneration

Figure 2

From: ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

Figure 2

The levels of inhibitory neurons and synapses (GAD67) and of the presynaptic marker synaptophysin in 4-month-old apoE3 and apoE4 mice. (A) GAD67 immunohistochemistry. Representative images (X20 magnification) of the CA3 subfield are presented on the left. Quantification of the results in the corresponding perikarya and dendritic fields (mean ± SEM; n=20 per group) of apoE3 mice (white bars) and apoE4 mice (black bars) is shown on the right. Scale = 120 μ. (B) Synaptophysin immunohistochemistry. Representative images (X20 magnification) of the CA3 subfield are presented on the left. Quantification of the results (mean ± SEM; n=20 per group) of apoE3 mice (white bars) and apoE4 mice (black bars) is shown on the right. Quantification of the GAD67 and synaptophysin immunohistochemical results was performed by computerized image analysis, as described in Materials and Methods. *p<0.005. Scale = 120 μ.

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Molecular Neurodegeneration

ISSN: 1750-1326