Figure 6

Time course of the effects of the apoE genotype in CA3 neurons of 1- and 4-month-old apoE3 and apoE4 mice. (A) The levels of VGlut in apoE3 (white bars) and apoE4 (black bars) mice. *p<0.02 for the effect of apoE genotype and p<0.005 for the effect of age. (B) The levels of the mitochondrial markers COX1 (left) and Tom40 (right) in apoE3 (white bars) and apoE4 (black bars) mice. *p<0.01 and p<0.002 of the effect for apoE genotype on Tom40 and COX1 levels, respectively, and p<0.001 for the effect of age on Tom40. (C) The levels of AT8 phosphorylated tau (left) and Aβ42 (right) in apoE3 (white bars) and apoE4 (black bars) mice. Two-way ANOVA revealed a significant effect for genotype×age for both the AT8 (p<0.0001) and Aβ42 (p<0.01) results. The significant post hoc comparisons of the effects of age and genotype are denoted by the hash marks as follows: ^#p<0.05, ^##p<0.01 and ^###p<0.001. Results in each of the panels (n=8 mice per group) were obtained at the same time and are presented relative to the 4-month-old apoE3 group.