Table 1 Summary of the effects of apoE4 on the hippocampus
Area parameter | CA3 | CA1 | DG | |||
|---|---|---|---|---|---|---|
Perikarya | Neurites | Perikarya | Neurites | Perikarya | Neurites | |
VGlut | −30±5 | −40±8 | −26±6 | |||
(% decrease) | P<0.0001 | P<0.001 | P<0.001 | |||
GAD67 | +14±6 | +14±7 | +5±10 | +9±4 | ||
(% increase) | N.S. | N.S. | N.S. | N.S. | ||
Tom40 | +42±15 | +7±17 | +88±20 | |||
(% increase) | P=0.04 | N.S. | P=0.004 | |||
COX1 | +143±33 | +17±12 | +18±11 | |||
(% increase) | P=0.03 | N.S. | N.S. | |||
Tau (AT8) | +150±21 | +70±17 | +65±14 | |||
(% increase) | P<0.0001 | P<0.001 | P<0.001 | |||
Aβ42 | +95±20 | +20±8 | +34±13 | |||
(% increase) | P<0.001 | N.S. | P=0.04 | |||