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Figure 4 | Molecular Neurodegeneration

Figure 4

From: Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice

Figure 4

Context-dependent freezing in APP swe /PS1 Δ E9  female mice and non-transgenic littermates following a high-sensitivity conditioning protocol. A deficit is not yet present in APP swe /PS1 Δ E9  females at 5 months of age [F(1,17)=0.684, p=0.420]. Context-dependent freezing deficits are detectable in APP swe /PS1 Δ E9  females at 8 months of age [*F(1,17)=5.943, p=0.026], but do not persist to 10 months of age [F(1,18)=2.824, p=0.110]. N-values: 5 month- nontg=9, APP/PS1=10, 8 month- nontg=8, APP/PS1=11, 10 month- nontg=12, APP/PS1=8. Error bars represent standard deviation.

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Molecular Neurodegeneration

ISSN: 1750-1326