Figure 1From: Overcoming barriers and thresholds – signaling of oligomeric Aβ through the prion protein to FynSchematic depiction of a popular model that ties extracellular oAβ-PrP interaction to cytosolic Fyn activation. The identity of the molecular player that communicates binding of oAβ to PrP into the cell is currently not known. Tau has been ascribed a critical role in the delivery of Fyn to the cytosolic face of the membrane.Back to article page