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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Overcoming barriers and thresholds – signaling of oligomeric Aβ through the prion protein to Fyn

Figure 2

Possible scenarios and molecular players that may be operative in overcoming the membrane barrier required for PrP-to-Fyn signaling. (A) PrP may recruit NCAM into raft domains causing its association with PTPRA, a known activator of Fyn. (B) PrP may influence cellular attachment to laminin by interacting with multiple molecules known to play key roles in this cell-to-extracellular matrix interaction. A sub complex of integrins and L1 is known to activate SFKs, again possibly through interaction with PTPRA. (C) PrP may modulate activity of Fyn by interacting with Caveolin-1. The consequence of this interaction with regard to Fyn activity status is currently unclear or may not be consistent across experimental paradigms.

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