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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Autophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide

Figure 1

The presence of NG2 cells adjacent to the amyloid plaque. A. The presence of NG2 cells in the cortex of 14-month-old APPswe/PS1 mice (top) and control mice (bottom) was demonstrated by immunohistochemistry (IHC) using an anti-NG2 antibody. The amyloid plaque was demonstrated by thioflavin-S staining. Scale bars = 50 μm. B. A specified area in panel A is shown with higher magnifications. Scale bars = 20 μm. C. Activated NG2 cells in the hippocampus of APPswe/PS1 mice (6-15-month-old) and age matched control mice were quantified as described under the Materials and Methods. The results were presented as mean ± SD of five animals. **p < 0.01, ***p < 0.001, compared to age matched control mice. ##p < 0.01, ###p < 0.001, compared to 6-month-old APPswe/PS1 mice. D: The expression of NG2 mRNA in 12-month-old mice was determined by real time PCR as described under the Materials and Methods. The results were presented as mean ± SEM of five animals. **p < 0.01, compared to age matched control mice.

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