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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex

Figure 1

Nicotine enhanced sIPSC in PFC layer V pyramidal neurons. A-D, Representative sIPSC traces (A) and cumulative plots of the distribution of sIPSC amplitude (B) and frequency (C) in the absence (control, wash) or presence of nicotine (5 μM) recorded in a PFC pyramidal neuron. The blockade of sIPSC by bicuculline (10 μM) was also shown in A. Scale bars (A): 50 pA, 5s. D, Bar plot summary of the percentage increase of sIPSC amplitude and frequency by nicotine in the absence or presence of MEC (mecamylamine, 10 μM, a non-α7 nAChR antagonist) or MLA (methyllycaconitine, 1 μM, an α7 nAChR antagonist). *: p < 0.05, **: p < 0.005, ANOVA.

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Molecular Neurodegeneration

ISSN: 1750-1326