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Figure 4 | Molecular Neurodegeneration

Figure 4

From: Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex

Figure 4

The nicotinic effect on sIPSC was lost in PFC pyramidal neurons from 5xFAD mice. A-F, Representative sIPSC traces (A, D) and cumulative plots of the distribution of sIPSC amplitude (B, D) and frequency (C, E) in the absence (control, wash) or presence of nicotine (5 μM) recorded in layer V PFC pyramidal neurons from WT vs. 5xFAD mice. Scale bars (A): 50 pA, 5 s. G , Bar plot summary of the percentage increase of sIPSC amplitude and frequency by nicotine in WT vs. 5xFAD mice. *: p < 0.05, t-test.

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Molecular Neurodegeneration

ISSN: 1750-1326