Skip to main content
Figure 5 | Molecular Neurodegeneration

Figure 5

From: Aβ impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex

Figure 5

Aβ attenuated the nicotinic effect on layer I interneuron excitability. A, B, Representative spikes elicited by a depolarizing current pulse in the absence (control) or presence of nicotine (5 μM) recorded in PFC layer I GABAergic interneurons without (A) or with Aβ pre-treatment (B). Scale bars: 50mV, 100ms. C, Bar plot summary of the percentage increase of firing rate by nicotine in non-treated (−) and Aβ-pretreated layer I interneurons. Note that the effect of nicotine was calculated in two different groups based on the change of resting potential (ΔRm) by nicotine. *: p < 0.05, **: p < 0.01, ANOVA.

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326