Figure 6

Aβ did not alter the nicotinic effect on sEPSC in layer I interneurons. A-C, Representative sEPSC traces (A) and cumulative plots of the distribution of sEPSC amplitude (B) and frequency (C) in the absence (control) or presence of nicotine (5 μM) recorded in a PFC layer I interneuron. The blockade of sEPSC by DNQX (20 μM) and APV (40 μM) was also shown in A. Scale bars (A): 10pA, 15s. D - F , Representative sEPSC traces (D) and cumulative plots of the distribution of sEPSC amplitude (E) and frequency (F) in the absence or presence of nicotine recorded in a PFC layer I interneuron pre-treated with Aβ (1 μM, 3 hours). Scale bars (D): 10pA, 15s. G, Bar plot summary of the percentage change of sEPSC amplitude and frequency by nicotine in non-treated (−) and Aβ-pretreated layer I interneurons. H, Bar plot summary of the percentage increase of sEPSC frequency by nicotine in the absence or presence of MEC (10 μM) or MLA (1 μM). *: p < 0.005, ANOVA.