Figure 7

Inhibiting PKC blocked the nicotinic effect on sIPSC but not sEPSC. A-C, Representative sIPSC recordings (A) and cumulative plots of the distribution of sIPSC amplitude (B) and frequency (C) in the absence (control) or presence of nicotine (5 μM) recorded in a PFC pyramidal neuron pretreated with the PKC inhibitor GF109203X (1 μM). Scale bars (A): 100pA, 15s. D-F, Representative sEPSC traces (D) and cumulative plots of the distribution of sEPSC amplitude (E) and frequency (F) in the absence (control) or presence of nicotine (5 μM) recorded in a PFC layer I interneuron pretreated with GF109203X (1 μM). Scale bars (D): 10pA, 15s. G, H, Bar plot summary of the percentage change of sIPSC (G) or sEPSC (H) amplitude and frequency by nicotine in neurons pretreated without (−) or with GF109203X. *: p < 0.05, **: p < 0.01, t-test.