Figure 8
Highly specific PKC inhibitor blocked the nicotinic effect on sIPSC. A-C, Representative sIPSC traces (A) and cumulative plots of the distribution of sIPSC amplitude (B) and frequency (C) in the absence (control) or presence of nicotine (5 μM) recorded in a PFC pyramidal neuron pretreated with myristolated PKC inhibitor 20–28 (10 μM). Scale bars (A): 50 pA, 5 s. D, Bar plot summary of the percentage increase of sIPSC amplitude and frequency by nicotine in neurons pretreated without (−) or with myr-PKC20-28. *: p < 0.05, t-test.