Rapamycin delivered in chow increases autophagy in the spinal cord of RAG1−/−mice. Western blot analysis of LC3-II, mTOR and p-mTOR in the spinal cords of RAG1−/− mice fed vehicle or rapamycin containing chow for 3 months (A). Quantification of the levels of LC3-II in spinal cords of mice fed chow containing rapamycin for 3 months (n = 4) or vehicle chow (n = 4) (B). Quantification of mTOR (C), p-mTOR (D), ATG5 (E) and beclin-1 (F). *p < 0.05, **p < 0.01.