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Table 1 Parameter estimates in the constant-rate and risk-based models of primary neurodegeneration using FA values at the optic nerve

From: Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma

  N 0 r 0 β γ R 2 P F-test
Constant-rate model
 Quantitative FA 0.64 0.0024 0.35 <0.05
 Relative FA 0.0047 0.36 <1.0×10-4
Risk-based model
Constant-risk model
 Quantitative FA 0.72 0.0081 0.67 <1.0×10-3
 Relative FA 0.0084 0.89 <1.0×10-5
Variable-risk model
 Quantitative FA 0.73 0.0016 0.064 0.94 <1.0×10-6 F 1,9  = 38.6*, P < 0.005
 Relative FA 0.0019 0.057 0.98 <1.0×10-7 F 1,10  = 37.9*, P < 0.0005
Heterogeneity model
 Quantitative FA 0.95 0.0031 0.060 0.58 0.96 <1.0×10-7 F 1,8  = 3.5**, N.S.
 Relative FA 0.0019 0.057 0.93 0.98 <1.0×10-8 F 1,9  = 0.6**, N.S.
  1. The quantitative and relative FA values were obtained from a region of interest in the glaucomatous optic nerve and from a ratio of FA between glaucomatous and control (contralateral) optic nerve, respectively. *F-test compared two nested models of constant-risk and variable-risk, taking into account the additional parameter β in the latter. **F-test compared two nested models of variable-risk and heterogeneity model, taking into account the additional parameter γ in the latter. N.S, not statistically significant.