Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma

Table 1 Parameter estimates in the constant-rate and risk-based models of primary neurodegeneration using FA values at the optic nerve

	N ₀	r ₀	β	γ	R ²	P	F-test
Constant-rate model
Quantitative FA	0.64	0.0024	—	—	0.35	<0.05	—
Relative FA	—	0.0047	—	—	0.36	<1.0×10^-4	—
Risk-based model
Constant-risk model
Quantitative FA	0.72	0.0081	—	—	0.67	<1.0×10^-3	—
Relative FA	—	0.0084	—	—	0.89	<1.0×10^-5	—
Variable-risk model
Quantitative FA	0.73	0.0016	0.064	—	0.94	<1.0×10^-6	F_1,9 = 38.6*, P < 0.005
Relative FA	—	0.0019	0.057	—	0.98	<1.0×10^-7	F_1,10 = 37.9*, P < 0.0005
Heterogeneity model
Quantitative FA	0.95	0.0031	0.060	0.58	0.96	<1.0×10^-7	F_1,8 = 3.5**, N.S.
Relative FA	—	0.0019	0.057	0.93	0.98	<1.0×10^-8	F_1,9 = 0.6**, N.S.

The quantitative and relative FA values were obtained from a region of interest in the glaucomatous optic nerve and from a ratio of FA between glaucomatous and control (contralateral) optic nerve, respectively. *F-test compared two nested models of constant-risk and variable-risk, taking into account the additional parameter β in the latter. **F-test compared two nested models of variable-risk and heterogeneity model, taking into account the additional parameter γ in the latter. N.S, not statistically significant.

ISSN: 1750-1326