Figure 1

AHNPC proliferation in PS1 M146V KI mice following exposure to SH or EE housing conditions. (A) Representative images of BrdU+ AHNPCs (yellow) in the SGL of PS1^+/+, PS1^M146V/+ or PS1^{M146V/ M146V} mice, exposed to SH or EE conditions for one month, injected with a single i.p dose of 100 mg/kg of BrdU and sacrificed 24 hr later. NeuN, green. Scale bar, 100 μm. (B) Quantification of total BrdU+ cells in SGL. Two-way ANOVA followed by post-hoc Tukey test; N = 10, 10, 9 for SH animals, and 10, 12, 11 for EE animals (m ± SEM). ** p < 0.01.