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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors

Figure 2

EE-induced differentiation of AHNPC in PS1 M146V KI mice. (A) Representative images of BrdU+/Prox1+ (A.i), BrdU+/β-III tubulin+ (A.ii), BrdU+/NeuroD1+ (A.iii), BrdU+/NeuN+ (A.iv), BrdU+/GFAP+ (A.v) or BrdU+/s100β+ (A.vi) co-labeled cells in PS1+/+ mice exposed to EE condition, injected with a single i.p dose of 100 mg/kg of BrdU and sacrificed 2 weeks later. Scale bar, 25 μm. Inserts inside each panel shows subfield of images captured through individual channels and the respective overlays highlighting cells co-labeling of BrdU and mentioned antigenic marker of differentiation. (B) Quantification of co-labeled cells with BrdU and markers of differentiation in DG of PS1+/+, PS1M146V/+ or PS1M146V/ M146V mice exposed to SH or EE housing condition. Two-way ANOVA followed by post-hoc Tukey test for analyzing multiple groups or T-test; N = 7, 8 (SH vs. EE, PS1+/+); 6, 8 (SH vs. EE, PS1M146V/+); 6, 6 (SH vs. EE, PS1M146V/ M146V) (m ± SEM). * p < 0.05, ** p < 0.01, #p = 0.075.

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