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Figure 7 | Molecular Neurodegeneration

Figure 7

From: Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis

Figure 7

Anterior horn region of lumbar spinal cord sections from mice at 220 days. Motor neuron choline acetyltransferase (ChAT) positive cells (A-C, arrows) co-localized with SOD1 positive staining (D-F, arrows). H46R/H48Q mice exhibited small intracellular peri-nuclear SOD1 reactive punctae (E, arrows), while H46R/H48QxHSF1 tissues had a more even intracellular distribution of SOD1 staining (F). This corresponded with differences in HSP70 distribution to SOD1 reactive punctae in H46R/H48Q mice (H) while in contrast, co-localization with ChAT reactive cells in H46R/H48QxHSF1 mice was stronger (I). Scale bar represents 10 μm.

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Molecular Neurodegeneration

ISSN: 1750-1326