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Figure 8 | Molecular Neurodegeneration

Figure 8

From: Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis

Figure 8

Anterior horn region of lumbar spinal cord sections from mice at 220 days. SOD1 staining (A-C) and small SOD1 positive punctae in H46R/H48Q vs. H46R/H48QxHSF1 tissues (C, arrows) co-localized diffusely with αB-crystallin throughout WT TG and H46R/H48QxHSF1 tissues (D,F). Strikingly, αB-crystallin staining appeared more punctate and localized to cell nuclei of SOD1 expressing cells (E,H, arrows and G-I) in H46R/H48Q tissues. Scale bar represents 10μm.

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Molecular Neurodegeneration

ISSN: 1750-1326