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Table 1 Protein identification table and hydrophobic ratios

From: Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis

Protein Name Accession # Mass Values Searched Mass Values Matched Mowse Score Probability of false hit Percent Sequence Coverage Fold H46R/H48Q /WT TG Sypro Fold H46R/H48Q /WT TG BisANS:Sypro P value
Heat shock cognate 71 kDa protein (Hsc70) P63017 44 15 108 2.3e-06 28 1.43 (0.06) 1.37* 0.0001
36 13 86 4.1e-04 25
85 19 96 3.4e-05 33
102 25 110 1.4e-06 37
Dihydropyrimidinase-related protein 2 (Dpysl2) O08553 27 9 70 1.5e-02 19 1.33 (0.16) 2.06* 0.0080
52 12 71 1.2e-02 24 1.24 (0.31) 2.19* 0.0256
Glial fibrillary acidic protein isoform 1 (Gfap) P03995 87 24 148 2.3e-10 46 0.95 (0.32) 1.91* 0.0119
Tubulin beta-4B chain (Tubb4b) P68372 45 13 97 2.6e-05 27 1.25 (0.33) 2.08* 0.0062
Alpha-enolase (Eno1) P17182 37 18 183 7.2e-14 42 0.99 (0.98) 3.08* 0.0118
Actin, cytoplasmic 2 (Actg1) P63260 76 16 101 1.1e-05 45 1.62 (0.01) 0.84 0.0467
29 9 80 1.5e-03 30 1.63 (<.01) 0.72* 0.0020
Fructose-bisphosphate aldolase C (Aldoc) P05063 33 15 138 2.3e-09 45 1.13 (0.65) 1.13 0.0128
65 16 116 3.6e-07 46 0.96 (0.92) 2.98* 0.0189
L-lactate dehydrogenase B chain (Ldhb) P16125 35 9 76 3.5e-03 20 1.00 (0.99) 1.67* 0.0284
46 10 77 2.6e-03 28 1.11 (0.64) 1.21 0.7792
Phosphoglycerate mutase 1 (Pgam1) Q9DBJ1 37 9 85 4.5e-04 46 1.64 (0.20) 2.07* 0.0136
29 11 125 4.6e-08 52 1.42 (0.16) 1.14 0.6404
14-3-3 zeta (Ywhaz) P63101 67 13 80 1.6e-03 35 3.25(<.01) 0.35*** 0.0006
14-3-3 protein gamma (Ywhag) P61982 55 12 78 2.3e-03 31 2.26 (<.01) 0.47*** 0.0001
Peroxiredoxin-6 (Prdx6) O08709 39 15 135 4.6e-09 53 1.48 (0.02) 0.75* 0.0442
Ubiquitin carboxy-terminal hydrolase L1 (Uchl1) Q9R0P9 40 10 75 4.2e-03 42 2.28 (0.02) 0.55* 0.0141
28 10 90 1.6e-04 42 2.11 (0.04) 0.57** 0.0006
Adenylate kinase isoenzyme 1 (Ak1) Q9R0Y5 15 6 73 7.6e-03 37 1.33 (0.48) 0.59* 0.0113
Phosphatidylethanolamine-binding protein 1 (Pebp1) P70296 15 6 82 8.1e-04 48 1.82 (0.04) 0.66* 0.0179
12 5 70 1.5e-02 36 1.36 (0.20) 0.85 0.6637
Peptidyl-prolyl cis-trans isomerase A (Ppia) P17742 56 18 113 7.2e-07 57 0.76 (0.37) 1.62 0.0356
48 14 91 1.1e-04 40 1.11 (0.76) 4.44** 0.0106
Human Cu, Zn Superoxide Dismutase (SOD1) P00441 40 8 76 7.0e-03 47 0.42 (<.01) 1.75* 0.0241
14 6 80 2.2e-03 28 0.52 (0.04) 1.13 0.0335
36 8 67 4.6e-02 34 0.45 (0.01) 2.08** 0.0051
   28 7 74 9.2e-03 38 0.63 (0.13) 1.46* 0.0046
  1. Protein IDs and gene names (in parentheses) are shown as well as fold-changes in their respective hydrophobic ratios and abundance with respect to matched WT TG spots. Statistical significance is indicated by asterisks *p = 0.05, **p = 0.01, ***p < 0.01 for ANOVA tests and p values of student’s t test are reported in parentheses.
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Molecular Neurodegeneration

ISSN: 1750-1326