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Table 1 Protein identification table and hydrophobic ratios

From: Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis

Protein Name

Accession #

Mass Values Searched

Mass Values Matched

Mowse Score

Probability of false hit

Percent Sequence Coverage

Fold H46R/H48Q /WT TG Sypro

Fold H46R/H48Q /WT TG BisANS:Sypro

P value

Heat shock cognate 71 kDa protein (Hsc70)

P63017

44

15

108

2.3e-06

28

1.43 (0.06)

1.37*

0.0001

36

13

86

4.1e-04

25

85

19

96

3.4e-05

33

102

25

110

1.4e-06

37

Dihydropyrimidinase-related protein 2 (Dpysl2)

O08553

27

9

70

1.5e-02

19

1.33 (0.16)

2.06*

0.0080

52

12

71

1.2e-02

24

1.24 (0.31)

2.19*

0.0256

Glial fibrillary acidic protein isoform 1 (Gfap)

P03995

87

24

148

2.3e-10

46

0.95 (0.32)

1.91*

0.0119

Tubulin beta-4B chain (Tubb4b)

P68372

45

13

97

2.6e-05

27

1.25 (0.33)

2.08*

0.0062

Alpha-enolase (Eno1)

P17182

37

18

183

7.2e-14

42

0.99 (0.98)

3.08*

0.0118

Actin, cytoplasmic 2 (Actg1)

P63260

76

16

101

1.1e-05

45

1.62 (0.01)

0.84

0.0467

29

9

80

1.5e-03

30

1.63 (<.01)

0.72*

0.0020

Fructose-bisphosphate aldolase C (Aldoc)

P05063

33

15

138

2.3e-09

45

1.13 (0.65)

1.13

0.0128

65

16

116

3.6e-07

46

0.96 (0.92)

2.98*

0.0189

L-lactate dehydrogenase B chain (Ldhb)

P16125

35

9

76

3.5e-03

20

1.00 (0.99)

1.67*

0.0284

46

10

77

2.6e-03

28

1.11 (0.64)

1.21

0.7792

Phosphoglycerate mutase 1 (Pgam1)

Q9DBJ1

37

9

85

4.5e-04

46

1.64 (0.20)

2.07*

0.0136

29

11

125

4.6e-08

52

1.42 (0.16)

1.14

0.6404

14-3-3 zeta (Ywhaz)

P63101

67

13

80

1.6e-03

35

3.25(<.01)

0.35***

0.0006

14-3-3 protein gamma (Ywhag)

P61982

55

12

78

2.3e-03

31

2.26 (<.01)

0.47***

0.0001

Peroxiredoxin-6 (Prdx6)

O08709

39

15

135

4.6e-09

53

1.48 (0.02)

0.75*

0.0442

Ubiquitin carboxy-terminal hydrolase L1 (Uchl1)

Q9R0P9

40

10

75

4.2e-03

42

2.28 (0.02)

0.55*

0.0141

28

10

90

1.6e-04

42

2.11 (0.04)

0.57**

0.0006

Adenylate kinase isoenzyme 1 (Ak1)

Q9R0Y5

15

6

73

7.6e-03

37

1.33 (0.48)

0.59*

0.0113

Phosphatidylethanolamine-binding protein 1 (Pebp1)

P70296

15

6

82

8.1e-04

48

1.82 (0.04)

0.66*

0.0179

12

5

70

1.5e-02

36

1.36 (0.20)

0.85

0.6637

Peptidyl-prolyl cis-trans isomerase A (Ppia)

P17742

56

18

113

7.2e-07

57

0.76 (0.37)

1.62

0.0356

48

14

91

1.1e-04

40

1.11 (0.76)

4.44**

0.0106

Human Cu, Zn Superoxide Dismutase (SOD1)

P00441

40

8

76

7.0e-03

47

0.42 (<.01)

1.75*

0.0241

14

6

80

2.2e-03

28

0.52 (0.04)

1.13

0.0335

36

8

67

4.6e-02

34

0.45 (0.01)

2.08**

0.0051

  

28

7

74

9.2e-03

38

0.63 (0.13)

1.46*

0.0046

  1. Protein IDs and gene names (in parentheses) are shown as well as fold-changes in their respective hydrophobic ratios and abundance with respect to matched WT TG spots. Statistical significance is indicated by asterisks *p = 0.05, **p = 0.01, ***p < 0.01 for ANOVA tests and p values of student’s t test are reported in parentheses.
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Molecular Neurodegeneration

ISSN: 1750-1326