Figure 1From: Behavioral and transcriptome alterations in male and female mice with postnatal deletion of TrkB in dorsal striatal medium spiny neuronsBaseline striatal TrkB level and locomotor activity in D9ΔTrkB mice. (a) Baseline levels of striatal TrkB.FL and TrkB.T1 are equal in fB/fB male and female mice. Densitometric values were normalized to actin. Blot is representative of N = 6, p > 0.05 (t-test). (b) Relative to fB/fB, D9ΔTrkB male and female mice demonstrate approximately a 50% decrease in striatal TrkB.FL (N = 3–4,*** P < 0.005, t-test). There is a trend towards a small decrease in TrkB.T1 (N = 3, P = 0.06, t-test). Densitometric values were normalized to actin, and fB/fB levels were arbitrarily set to equal 1. (c) Down-regulation of striatal MSN TrkB.FL does not alter baseline total activity, but there is a genotype-independent increase in activity in female mice relative to males (N = 8-12/group, ** P < 0.01 two-way ANOVA for sex factor).Back to article page