Table 2 Top canonical pathways associated with TrkB deletion in mouse striatal MSNs
Canonical pathway: | -log (p-value): | Ratio: | Molecules: |
|---|---|---|---|
Thrombin signaling | 2.69E + 00 | 5.34E-02 | ARHGEF10, MPRIP, GATA1, RHOT2, ADCY1, GNB5, CAMK1G, HRAS, PRKCH, GNG7, PRKCB |
Protein kinase A signaling | 2.63E + 00 | 4.28E-02 | SHH, PTPN7, PTPRE, SMAD3, DUSP6, GNB5, PTPN5, TCF7, GNG7, PTEN, ADD3, ADCY1, SMAD4, RYR1, PRKCH, CDC16, PRKCB |
Galpha(i) signaling | 2.44E + 00 | 6.06E-02 | GRM8, NPY1R, ADCY1, GNB5, HRAS, ADRA2C, STAT3, GNG7 |
Prolactin signaling | 2.39E + 00 | 7.50E-02 | HRAS, PRKCH, STAT3, SOCS5, TCF7, PRKCB |
CXCR4 signaling | 2.36E + 00 | 5.36E-02 | EGR1, RHOT2, ADCY1, GNB5, HRAS, PRKCH, ELMO1, GNG7, PRKCB |
Glutamate receptor signaling | 2.18E + 00 | 7.25E-02 | GRM8, SLC1A1, HOMER1, GNG7, GRIK1 |
Galpha(s) signaling | 2.11E + 00 | 5.79E-02 | RGS2, ADD3, ADCY1, GNB5, RYR1, HTR6, GNG7 |
Cell cycle: G1/S checkpoint regulation | 2.06E + 00 | 7.58E-02 | PA2G4, HDAC8, SMAD3, SMAD4, CDKN1B |
Beta-adrenergic signaling | 2.04E + 00 | 5.71E-02 | ADCY1, GNB5, HRAS, PRKCH, GNG7, PRKCB |
Phospholipase C signaling | 2.04E + 00 | 4.23E-02 | ARHGEF10, MPRIP, HDAC8, RHOT2, ADCY1, GNB5, ITGA5, HRAS, PRKCH, GNG7, PRKCB |
Neuregulin signaling | 2.00E + 00 | 5.88E-02 | ITGA5, HRAS, PRKCH, CDKN1B, PTEN, PRKCB |
G Beta gamma signaling | 2.00E + 00 | 5.13E-02 | ADCY1, GNB5, HRAS, PRKCH, GNG7, PRKCB |
RAR activation | 1.98E + 00 | 4.76E-02 | SMAD3, ADCY1, SMAD4, PRKCH, ERCC2, PTEN, PPARGC1A, RBP4, PRKCB |
Virus entry via endocytic pathways | 1.97E + 00 | 6.06E-02 | ITGA5, TFRC, HRAS, PRKCH, CXADR, PRKCB |
Chronic myeloid leukemia signaling | 1.86E + 00 | 5.71E-02 | PA2G4, HDAC8, SMAD3, SMAD4, HRAS, CDKN1B |
Glioma signaling | 1.84E + 00 | 5.36E-02 | PA2G4, CAMK1G, HRAS, PRKCH, PTEN, PRKCB |
Axonal guidance signaling | 1.77E + 00 | 3.42E-02 | SHH, GNB5, HRAS, SEMA6B, ITGA5, FZD1, SLIT2, GIT1, GNG7, NTNG1, SEMA3A, SUFU, BAIAP2, ABLIM2, PRKCH, PRKCB |
Breast cancer regulation by stathmin1 | 1.73E + 00 | 4.35E-02 | ARHGEF10, ADCY1, GNB5, CAMK1G, HRAS, PRKCH, CDKN1B, GNG7, PRKCB |
Molecular mechanisms of cancer | 1.60E + 00 | 3.44E-02 | SHH, PA2G4, SMAD3, RHOT2, HRAS, FZD1, ARHGEF10, SUFU, ADCY1, SMAD4, PRKCH, CDKN1B, PRKCB |
Renin-angiotensin signaling | 1.60E + 00 | 4.80E-02 | ADCY1, HRAS, SHC3, PRKCH, STAT3, PRKCB |
CREB signaling in neurons | 1.56E + 00 | 3.94E-02 | GRM8, ADCY1, GNB5, HRAS, PRKCH, GNG7, GRIK1, PRKCB |
Androgen signaling | 1.55E + 00 | 4.17E-02 | SMAD3, GNB5, PRKCH, ERCC2, GNG7, PRKCB |
ErbB2-ErbB3 signaling | 1.51E + 00 | 6.67E-02 | HRAS, STAT3, CDKN1B, PTEN |
Calcium signaling | 1.48E + 00 | 3.79E-02 | TNNT1, HDAC8, CAMK1G, TPM2, RYR1, TRPC4, CASQ2, GRIK1 |
14-3-3-mediated signaling | 1.45E + 00 | 4.96E-02 | STK11, TSC2, HRAS, PRKCH, CDKN1B, PRKCB |
P2Y purigenic receptor signaling pathway | 1.42E + 00 | 4.35E-02 | ADCY1, GNB5, HRAS, PRKCH, GNG7, PRKCB |
PTEN signaling | 1.42E + 00 | 4.44E-02 | INPP5F, FLT1, ITGA5, HRAS, CDKN1B, PTEN |
IL-8 signaling | 1.41E + 00 | 3.90E-02 | FLT1, RHOT2, GNB5, HRAS, PRKCH, IRAK3, GNG7, PRKCB |
cAMP-mediated signaling | 1.41E + 00 | 4.02E-02 | RGS2, GRM8, NPY1R, DUSP6, ADCY1, CAMK1G, ADRA2C, HTR6, STAT3 |