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Figure 6 | Molecular Neurodegeneration

Figure 6

From: Mitochondrial quality, dynamics and functional capacity in Parkinson’s disease cybrid cell lines selected for Lewy body expression

Figure 6

Nucleoid content in cells containing CLB in PD Orig and PD CLB cell lines. (A,B,C) Representative images of cells containing CLB in PDOrig and PDCLB pairs. Cells were triple-stained with PicoGreen, Congo red, and MitoTracker Deep Red (green: DNA, red: CLB, purple: mitochondria). (A) CLB-containing cell in PD61Orig contained nucleoids that co-localized with mitochondria. PD61CLB (bottom panel) also featured CLB-containing cells with contained nucleoids. (B) CLB-containing cells from PD63Orig (top panel) and PD63CLB (bottom panel) did not contain nucleoids. (C) Cells containing CLB in PD67Orig (top panel) and PD67CLB (bottom panel) contained nucleoids. Scale bar=5μm-.

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