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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease

Figure 2

PMP70 protein levels and distribution in the hippocampus of WT and Tg mice. (a) Densitometric values of PMP70 WB, obtained analyzing the hippocampal protein extracts of 3-, 6-, 9-, 12-, and 18-month-old WT and Tg mice. Data are expressed as mean ± SD. *P <0.05; **P <0.01; ***P <0.001. (b) Immunohistochemical distribution of PMP70 in CA1 hippocampal field of 3-, 6-, 9-, and 18-month-old WT and Tg mice. or, stratum oriens; pyr, stratum pyramidale; rad, stratum radiatum. Scale bars, 25 μm. (c) PMP70 pre-embedding immunoelectron microscopy of 3-month-old CA1 pyramidal neurons of WT and Tg animals. In both genotypes positive peroxisomes (arrows) are observed and they appear more numerous in the cytoplasm of Tg neurons. N, neuronal nucleus; m, mitochondrion. Scale bars, 1 μm.

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Molecular Neurodegeneration

ISSN: 1750-1326