MEMRI of control nonTg and mutant tau expressing rTg4510 mice. A) Normalize signal intensity across various ROI (expressed as mean Z scores of voxels equal or above 1). B) Active volume across various ROI (expressed as mean volume – in mm3 - of voxels equal or above 1). C) Mean intensity projection images highlighting intensity and active volume in areas of the striatum, hippocampus and amygdala (purple, yellow-orange and light blue, respectively). *p < 0.05 t-test comparing means of nonTg vs rTg4510 mice.