From: ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer’s disease
APOE Haplotype† | rs429358 | rs7412 | rs199768005 | rs769452 | Minor allele frequency (%) | Logistic regression* | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
p.C112R | p.R158C | p.V236E | p.L28P | Univariate | Multivariate | |||||||||
Base | AA | Base | AA | Base | AA | Base | AA | AD | CON | OR | P | OR | P | |
ϵ2 allele | T | Cys | t | Cys | T | Val | T | Leu | 3.15% | 8.50% | 0.35 (0.30-0.40) | <2x10−16 | 0.46 (0.38-0.54) | <2x10−16 |
ϵ3a allele | T | Cys | C | Arg | T | Val | T | Leu | 58.0% | 79.0% | 0.35 (0.32-0.37) | <2x10−16 | 1.00 (REF) | REF |
ϵ3b allele | T | Cys | C | Arg | c | Glu | T | Leu | 0.024% | 0.23% | 0.11 (0.02-0.36) | 2.32x10−03 | 0.10 (0.02-0.35) | 2.16x10−03 |
ϵ4a allele | C | Arg | C | Arg | T | Val | T | Leu | 37.4% | 12.3% | 5.00 (4.52-5.50) | <2x10−16 | 4.80 (4.35-5.30) | <2x10−16 |
ϵ4b allele | C | Arg | C | Arg | T | Val | c | Pro | 0.62% | 0.26% | 2.49 (1.45-4.41) | 1.17x10−03 | 0.91 (0.51-1.66) | 0.75 |