Table 1 Temporal classification of up-regulated retinal gene cluster changes following ONC
Gene ontology | Clusters | Time point | P value |
|---|---|---|---|
Molecular function | Structural eye protein | 3 dpc | 1.90E-06 |
| Â | Eye development | 3 dpc | 4.50E-03 |
| Â | Extracellular matrix binding | 3 dpc | 5.30E-03 |
| Â | Calcium ion binding | 7 dpc | 3.30E-02 |
| Â | Structural eye lens protein | 21 dpc | 2.20E-11 |
| Â | Structural molecular activity | 21 dpc | 4.60E-06 |
Biological process | Response to wounding | 3 dpc | 1.00E-04 |
| Â | Inflammatory response | 3 dpc | 3.80E-04 |
| Â | Defense response | 3 dpc | 5.90E-04 |
| Â | Positive regulation of immune system response | 3 dpc | 1.20E-02 |
| Â | Rho protein signal transduction | 3 dpc | 5.90E-03 |
| Â | Regulation of signal proliferation | 3 dpc | 2.70E-02 |
| Â | Defense response | 7 dpc | 5.40E-04 |
| Â | Inflammatory response | 7 dpc | 1.60E-02 |
| Â | Response to wounding | 7 dpc | 4.70E-02 |
| Â | Sensory perception | 14 dpc | 8.80E-03 |
| Â | Neurological system process | 14 dpc | 2.30E-02 |
| Â | G-protein coupled receptor signaling pathway | 14 dpc | 3.90E-02 |
| Â | Macromolecular complex assembly | 28 dpc | 1.30E-02 |
| Â | DNA packaging | 28 dpc | 3.10E-02 |
| Â | Positive regulation of protein kinase activity | 28 dpc | 4.50E-02 |
Cellular component | Extracellular region part | 3 dpc | 3.20E-03 |
| Â | Extracellular matrix | 3 dpc | 7.60E-03 |
| Â | Lysosome | 3 dpc | 3.40E-02 |
| Â | Extracellular region part | 7 dpc | 3.50E-02 |
| Â | Microsome | 14 dpc | 1.70E-02 |
| Â | Intermediate filament | 14 dpc | 3.70E-02 |
| Â | Ribosome | 21 dpc | 5.00E-03 |