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Table 1 Temporal classification of up-regulated retinal gene cluster changes following ONC

From: Optic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice

Gene ontology Clusters Time point P value
Molecular function Structural eye protein 3 dpc 1.90E-06
  Eye development 3 dpc 4.50E-03
  Extracellular matrix binding 3 dpc 5.30E-03
  Calcium ion binding 7 dpc 3.30E-02
  Structural eye lens protein 21 dpc 2.20E-11
  Structural molecular activity 21 dpc 4.60E-06
Biological process Response to wounding 3 dpc 1.00E-04
  Inflammatory response 3 dpc 3.80E-04
  Defense response 3 dpc 5.90E-04
  Positive regulation of immune system response 3 dpc 1.20E-02
  Rho protein signal transduction 3 dpc 5.90E-03
  Regulation of signal proliferation 3 dpc 2.70E-02
  Defense response 7 dpc 5.40E-04
  Inflammatory response 7 dpc 1.60E-02
  Response to wounding 7 dpc 4.70E-02
  Sensory perception 14 dpc 8.80E-03
  Neurological system process 14 dpc 2.30E-02
  G-protein coupled receptor signaling pathway 14 dpc 3.90E-02
  Macromolecular complex assembly 28 dpc 1.30E-02
  DNA packaging 28 dpc 3.10E-02
  Positive regulation of protein kinase activity 28 dpc 4.50E-02
Cellular component Extracellular region part 3 dpc 3.20E-03
  Extracellular matrix 3 dpc 7.60E-03
  Lysosome 3 dpc 3.40E-02
  Extracellular region part 7 dpc 3.50E-02
  Microsome 14 dpc 1.70E-02
  Intermediate filament 14 dpc 3.70E-02
  Ribosome 21 dpc 5.00E-03
  1. Gene expression fold-change values were grouped individually from naïve eyes and ONC eyes out to 28 days post crush (dpc). Genes were highlighted based on fold values for up-regulated (≥1.5) retinal datasets. The selected genes were analyzed by gene ontology (GO) based cluster identification at each time point using DAVID. Significance was determined using the Benjamini multiple test correction, GO enrichment score χ2 test and Fishers Exact test (p < 0.05).