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Table 2 Temporal classification of down-regulated retinal gene cluster changes following ONC

From: Optic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice

Gene ontology Clusters Time point P value
Molecular function Structural eye lens protein 7 dpc 3.80E-15
  Structural eye lens protein 28 dpc 2.60E-14
  Pattern binding 28 dpc 3.80E-02
Biological process Chromatin assembly 7 dpc 4.80E-04
  Regulation of axonogenesis 21 dpc 7.40E-03
  G-protein coupled receptor signaling pathway 21 dpc 2.00E-04
  Neurological system process 21 dpc 7.10E-03
  Intermediate filament bundle process 21 dpc 6.40E-05
  Microtubule based process 21 dpc 5.10E-03
  Axonogenesis 21 dpc 1.70E-02
  Neuron projection morphogenesis 21 dpc 2.00E-02
  Neuron differentiation 21 dpc 4.20E-02
  Cell morphogenesis involved in differentiation 28 dpc 1.20E-02
Cellular component Nucleosome 7 dpc 7.50E-05
  Neuron projection 21 dpc 5.00E-05
  Axon 21 dpc 6.50E-05
  Neurofilament 21 dpc 1.60E-04
  Intrinsic to membrane 21 dpc 1.30E-02
  Neuron projection 28 dpc 9.90E-03
  Chromosome 28 dpc 3.10E-02
  1. Gene expression fold-change values were grouped individually from naïve eyes and ONC eyes out to 28 days post crush (dpc). Genes were highlighted based on fold values for down-regulated (≤ −1.5) retinal datasets. The selected genes were analyzed by gene ontology (GO) based cluster identification at each time point using DAVID. Significance was determined using the Benjamini multiple test correction, GO enrichment score χ2 test and Fishers Exact test (p < 0.05).