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Table 2 Temporal classification of down-regulated retinal gene cluster changes following ONC

From: Optic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice

Gene ontology

Clusters

Time point

P value

Molecular function

Structural eye lens protein

7 dpc

3.80E-15

 

Structural eye lens protein

28 dpc

2.60E-14

 

Pattern binding

28 dpc

3.80E-02

Biological process

Chromatin assembly

7 dpc

4.80E-04

 

Regulation of axonogenesis

21 dpc

7.40E-03

 

G-protein coupled receptor signaling pathway

21 dpc

2.00E-04

 

Neurological system process

21 dpc

7.10E-03

 

Intermediate filament bundle process

21 dpc

6.40E-05

 

Microtubule based process

21 dpc

5.10E-03

 

Axonogenesis

21 dpc

1.70E-02

 

Neuron projection morphogenesis

21 dpc

2.00E-02

 

Neuron differentiation

21 dpc

4.20E-02

 

Cell morphogenesis involved in differentiation

28 dpc

1.20E-02

Cellular component

Nucleosome

7 dpc

7.50E-05

 

Neuron projection

21 dpc

5.00E-05

 

Axon

21 dpc

6.50E-05

 

Neurofilament

21 dpc

1.60E-04

 

Intrinsic to membrane

21 dpc

1.30E-02

 

Neuron projection

28 dpc

9.90E-03

 

Chromosome

28 dpc

3.10E-02

  1. Gene expression fold-change values were grouped individually from naïve eyes and ONC eyes out to 28 days post crush (dpc). Genes were highlighted based on fold values for down-regulated (≤ −1.5) retinal datasets. The selected genes were analyzed by gene ontology (GO) based cluster identification at each time point using DAVID. Significance was determined using the Benjamini multiple test correction, GO enrichment score χ2 test and Fishers Exact test (p < 0.05).