Skip to main content

Table 3 Temporal classification of up-regulated ON gene cluster changes following ONC

From: Optic nerve crush induces spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice

Gene ontology

Clusters

Time point

P value

Molecular function

Chemokine activity

3 dpc

6.50E-06

 

Growth factor binding

3 dpc

1.10E-03

 

Actin binding

3 dpc

9.10E-03

 

Serine type endopeptidase inhibitor activity

7 dpc

7.10E-04

 

Chemokine activity

14 dpc

6.70E-09

 

Cytokine activity

14 dpc

6.00E-06

 

Chemokine activity

21 dpc

1.60E-04

 

Cytokine binding

21 dpc

4.30E-04

 

Ion channel activity

28 dpc

1.20E-09

 

Calcium ion binding

28 dpc

7.70E-07

 

GABA receptor activity

28 dpc

4.30E-04

 

Neurotransmitter binding

28 dpc

4.00E-03

 

Calcium channel activity

28 dpc

9.10E-03

 

Protein kinase activator activity

28 dpc

8.80E-03

Biological process

Defense response

3 dpc

6.20E-05

 

Translation

3 dpc

1.20E-03

 

Cell cycle

3 dpc

3.10E-06

 

Leukocyte activation

3 dpc

2.10E-04

 

Actin cytoskeleton organization

3 dpc

6.80E-03

 

Regulation of adaptive immune response

3 dpc

3.60E-04

 

Positive regulation of programmed cell death

3 dpc

1.20E-03

 

Positive regulation of axonogenesis

3 dpc

2.10E-02

 

Sensory perception

7 dpc

2.90E-02

 

Immune response

14 dpc

3.40E-08

 

Chemotaxis

14 dpc

2.60E-07

 

Response to wounding

14 dpc

1.10E-06

 

Cell activation

14 dpc

5.70E-05

 

Defense response

21 dpc

1.60E-08

 

Response to wounding

21 dpc

4.00E-06

 

Chemotaxis

21 dpc

2.60E-06

 

Regulation of adaptive immune response

21 dpc

5.40E-06

 

Phagocytosis

21 dpc

7.10E-03

 

Neuropeptide signaling pathway

21 dpc

2.50E-02

 

Ion transport

28 dpc

2.70E-06

 

Transmission of nerve impulse

28 dpc

6.30E-08

 

Synaptic transmission

28 dpc

1.20E-06

 

Synaptic vesicle transport

28 dpc

4.60E-03

 

Regulation of synaptic plasticity

28 dpc

2.40E-03

 

Regulation of synaptic transmission

28 dpc

6.40E-03

 

Synaptogenesis

28 dpc

1.50E-02

 

Cell adhesion

28 dpc

3.20E-02

Cellular component

Chromosome

3 dpc

1.50E-09

 

Extracellular region part

3 dpc

8.80E-08

 

Collagen

3 dpc

6.00E-03

 

Focal adhesion

3 dpc

7.20E-03

 

Anchoring junction

3 dpc

2.50E-02

 

Extracellular region

7 dpc

9.80E-04

 

Extracellular region

14 dpc

3.30E-03

 

Cell surface

14 dpc

2.80E-04

 

Extracellular region

21 dpc

2.60E-04

 

Synapse part

28 dpc

1.90E-13

 

Postsynaptic membrane

28 dpc

1.90E-07

 

Neuron projection

28 dpc

3.30E-07

 

Dendrite

28 dpc

2.30E-05

 

Synaptosome

28 dpc

3.10E-04

 

Postsynaptic density

28 dpc

5.60E-03

 

Synaptic vesicle

28 dpc

2.60E-03

  1. Gene expression fold-change values were grouped individually from naïve eyes and ONC eyes out to 28 days post crush (dpc). Genes were highlighted based on fold values for up-regulated (≥1.5) optic nerve datasets. The selected genes were analyzed by gene ontology (GO) based cluster identification at each time point using DAVID. Significance was determined using the Benjamini multiple test correction, GO enrichment score χ2 test and Fishers Exact test (p < 0.05).
Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326