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Table 1 Demographics

From: U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer’s disease due to autosomal dominant genetic mutations and trisomy 21

Control

PMI

Age of death

ApoE

Gender

BRAAK

Age onset

Mutation

BLSA-1313

n/a

92

3/3

f

II

  

BLSA-1471

n/a

87

2/3

m

II

  

BLSA-1517

16

71

4/4

f

II

  

BLSA-2027

7

86

2/3

m

IV

  

BLSA-2066

17

95

2/3

m

III

  

AD (PS-1):

       

E10-110

42

47

3/3

m

VI

30

M146V

UW-24

3.5

46

n/a

m

VI

39

G209V

UW-238

<24

51

n/a

f

V

41

G209V

UW-301

7

37

n/a

m

VI

31

I143T

UW-304

<24

58

n/a

m

V

48

G209V

UW-328

17.5

44

n/a

f

VI

38

A260V

AD (APP):

       

E12-24

5.5

54

3/3

m

VI

45

V7171I

UW-16514

n/a

72

n/a

f

VI

62

E693G

Down:

       

1

20

40

n/a

m

n/a

  

2

8

44

n/a

f

n/a

  

3

3

46

n/a

m

n/a

  

4

5

47

n/a

f

n/a

  

5

4.5

59

n/a

f

n/a

  

6

15

60

n/a

f

n/a

  
  1. n/a not available; BLSA Baltimore longitudinal study of aging; E Emory; UW University of Washington; Down syndrome cases from Rush University.
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Molecular Neurodegeneration

ISSN: 1750-1326