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Figure 4 | Molecular Neurodegeneration

Figure 4

From: Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5 – implications for dementia with Lewy bodies

Figure 4

Decreased number of hippocampal CA3 but not CA1 pyramidal cells in APP, α-syn, and α-syn/APP tg mice. A. Representative low- and high-photomicrographs of the hippocampal CA3 and CA1 regions of sections immunoreacted with NeuN. B. Stereological assessment of every 12th section revealed a significant decrease in the number of neurons in the CA3. C. However, the number of neurons in the CA1 region was unaffected across all tg mouse line. Statistical analysis was conducted using one-way ANOVA post hoc Dunnett’s compared to non-tg mice; * p-value < 0.05. For analysis N = 3 (3–4 mos old) from each line were utilized.

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Molecular Neurodegeneration

ISSN: 1750-1326