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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

Figure 2

TREM2 heterozygosity does not affect PBS-insoluble Aβ levels in 3-month old APPPS1-21 mice. (A) Mean concentrations of PBS-insoluble Aβ40 in cortical tissue from TREM2 WT (male, n = 13; female, n = 12) and TREM2 Het (male, n = 8; female n = 10) mice were determined by ELISA. Two-way ANOVA analysis found a significant effect of gender (F1,38 = 5.49, p = 0.02), but not genotype (F1,38 = 0.55, p = 0.46). (B) Mean concentrations of PBS-insoluble Aβ42 in cortical tissue from TREM2 WT (male, n = 13; female, n = 12) and TREM2 Het (male, n = 8; female n = 10) mice were determined by ELISA. Two-way ANOVA analysis found a significant effect of gender (F1,38 = 5.96, p = 0.02), but not genotype (F1,38 = 0.07, p = 0.79). Data are presented as mean ± SEM.

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