Figure 3
From: Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
Decreased plaque-associated microglia in TREM2 Het mice. (A-F) Representative images of Alexa568-HJ3.4-stained plaque and GFP-expressing microglia from TREM2 WT (A-C) and TREM2 Het (D-F) mice. (G) The number of microglia per 100 μm2 within a 20 μm2 radius of an Aβ plaque in TREM2 WT mice (25.1 ± 2.25, n = 10) and TREM2 Het mice (18.3 ± 1.24, n = 9) was compared using a Mann–Whitney test (p = 0.03). (H) The mean soma size off plaque-associated microglia in TREM2 WT mice (45.0 ± 2.23 μm2, n = 10) and TREM2 Het mice (37.9 ± 1.57 μm2, n = 9) was compared using a Mann–Whitney test (p = 0.03). (I) The percent area covered by plaque-associated microglia in TREM2 WT mice (14.1 ± 1.4%, n = 10) and TREM2 Het mice (8.8 ± 0.71%, n = 9) was compared using a Mann–Whitney test (p = 0.01).