TREM2 heterozygosity does not significantly affect the inflammatory milieu in 3-month old APPPS1-21 mice. (A) Quantification of relative gene expression of microglial markers and NOS2 in TREM2 WT and TREM2 Het mice (n = 4-6 mice/genotype). For each mRNA analyzed TREM2 Het values were normalized and compared to TREM2 WT values using a t-test followed by a Benjamini-Hochberg p-value correction for multiple comparisons. (B-D) Levels of inflammatory cytokines in cortical tissue from TREM2 WT (n = 6) and TREM2 Het (n = 6) mice were compared using a t-test followed by Benjamini-Hochberg p-value correction for multiple comparisons. Cytokine levels are plotted on different axis for clarity of presentation. All data are presented as mean ± SEM, *corrected p < 0.05.