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Table 1 Selected CSF AD biomarker candidates

From: Identification of longitudinally dynamic biomarkers in Alzheimer’s disease cerebrospinal fluid by targeted proteomics

Uniprot ID Identifier Protein Link to AD Change in AD
P01009 A1AT α-1-antitrypsin Neuroinflammation [1618, 3033]
P04217 A1BG α-1-beta-glycoprotein Unknown [17, 20, 34]
P02768 ALBU Albumin Aβ polymerization [17, 18]
P05067 A4 Amyloid precursor protein Aβ peptide precursor [35]
P51693 APLP1 Amyloid precursor-like protein 1 Beta and gamma secretase substrate [36]
P02649 APOE Apolipoprotein E Apolipoprotein, Aβ clearance [15, 17, 18, 20, 33, 37]
Q8TCZ8 APOE4 Apolipoprotein E4 Apolipoprotein, risk factor for AD [22]
P02749 APOH Apolipoprotein H (beta-2-glycoprotein 1) Apolipoprotein [15, 20, 21]
P61769 B2MG Beta-2-microglobulin Aβ-binding molecule [15, 17, 19, 20, 22, 3741]
P00450 CERU Ceruloplasmin Antioxidant [34, 42, 43]
P36222 CH3L1 Chitinase-3-like protein 1 (YKL-40) Neuroinflammation [15, 20, 22, 23, 44]
P10645 CMGA Chromogranin A Neurodegeneration [15, 19, 20, 22, 41, 4547]
P10909 CLUS Clusterin (ApoJ) Apolipoprotein, Aβ clearance [1518, 22, 33, 47]
Q12860 CNTN1 Contactin 1 Neurodegeneration [16, 18]
Q02246 CNTN2 Contactin 2 Neurodegeneration [16, 18]
P01024 CO3 Complement component C3 Neuroinflammation [18, 45, 48, 49]
P0C0L4 CO4 Complement component C4 Neuroinflammation [16, 22, 34, 49]
P01034 CYTC Cystatin C Aβ-binding molecule [15, 19, 20, 22, 32, 38, 41, 47]
O95502 NPTXR Neuronal pentraxin receptor Neurodegeneration [15, 18, 50]
Q92823 NRCAM NrCAM Neurodegeneration [22, 45, 51]
P00747 PLMN Plasminogen Aβ clearance [18]
P04156 PRIO Prion protein β Secretase BACE1 inhibitor [39, 40, 52]
P41222 PTGDS Prostaglandin-d2 synthase Aβ binding protein [16, 20]
P02753 RET4 Retinol binding protein Unknown [15, 17, 18, 37, 39, 40, 53, 54]
P08294 SODE Superoxide dismutase Target of oxidative damage in AD [15, 34]
P05452 TETN Tetranectin Neurodegeneration [15, 16]
P02787 TFRE (sero)transferrin Oxidative damage in AD [15, 17, 34, 39, 40]
P02766 TTHY Transthyretin Aβ-binding molecule [15, 17, 18, 22, 37, 39, 40, 5457]
P62760 VISL1 Visinin-like protein 1 Neurodegeneration [25, 26, 58]
P02774 VTDB Vitamin D Binding protein Aβ-binding molecule [15, 18, 39, 40]