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Table 1 Selected CSF AD biomarker candidates

From: Identification of longitudinally dynamic biomarkers in Alzheimer’s disease cerebrospinal fluid by targeted proteomics

Uniprot ID

Identifier

Protein

Link to AD

Change in AD

P01009

A1AT

α-1-antitrypsin

Neuroinflammation

[1618, 3033]

P04217

A1BG

α-1-beta-glycoprotein

Unknown

[17, 20, 34]

P02768

ALBU

Albumin

Aβ polymerization

[17, 18]

P05067

A4

Amyloid precursor protein

Aβ peptide precursor

[35]

P51693

APLP1

Amyloid precursor-like protein 1

Beta and gamma secretase substrate

[36]

P02649

APOE

Apolipoprotein E

Apolipoprotein, Aβ clearance

[15, 17, 18, 20, 33, 37]

Q8TCZ8

APOE4

Apolipoprotein E4

Apolipoprotein, risk factor for AD

[22]

P02749

APOH

Apolipoprotein H (beta-2-glycoprotein 1)

Apolipoprotein

[15, 20, 21]

P61769

B2MG

Beta-2-microglobulin

Aβ-binding molecule

[15, 17, 19, 20, 22, 3741]

P00450

CERU

Ceruloplasmin

Antioxidant

[34, 42, 43]

P36222

CH3L1

Chitinase-3-like protein 1 (YKL-40)

Neuroinflammation

[15, 20, 22, 23, 44]

P10645

CMGA

Chromogranin A

Neurodegeneration

[15, 19, 20, 22, 41, 4547]

P10909

CLUS

Clusterin (ApoJ)

Apolipoprotein, Aβ clearance

[1518, 22, 33, 47]

Q12860

CNTN1

Contactin 1

Neurodegeneration

[16, 18]

Q02246

CNTN2

Contactin 2

Neurodegeneration

[16, 18]

P01024

CO3

Complement component C3

Neuroinflammation

[18, 45, 48, 49]

P0C0L4

CO4

Complement component C4

Neuroinflammation

[16, 22, 34, 49]

P01034

CYTC

Cystatin C

Aβ-binding molecule

[15, 19, 20, 22, 32, 38, 41, 47]

O95502

NPTXR

Neuronal pentraxin receptor

Neurodegeneration

[15, 18, 50]

Q92823

NRCAM

NrCAM

Neurodegeneration

[22, 45, 51]

P00747

PLMN

Plasminogen

Aβ clearance

[18]

P04156

PRIO

Prion protein

β Secretase BACE1 inhibitor

[39, 40, 52]

P41222

PTGDS

Prostaglandin-d2 synthase

Aβ binding protein

[16, 20]

P02753

RET4

Retinol binding protein

Unknown

[15, 17, 18, 37, 39, 40, 53, 54]

P08294

SODE

Superoxide dismutase

Target of oxidative damage in AD

[15, 34]

P05452

TETN

Tetranectin

Neurodegeneration

[15, 16]

P02787

TFRE

(sero)transferrin

Oxidative damage in AD

[15, 17, 34, 39, 40]

P02766

TTHY

Transthyretin

Aβ-binding molecule

[15, 17, 18, 22, 37, 39, 40, 5457]

P62760

VISL1

Visinin-like protein 1

Neurodegeneration

[25, 26, 58]

P02774

VTDB

Vitamin D Binding protein

Aβ-binding molecule

[15, 18, 39, 40]