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Table 3 Summary of biomarkers that differ at baseline between diagnostic groups

From: Identification of longitudinally dynamic biomarkers in Alzheimer’s disease cerebrospinal fluid by targeted proteomics

 

Group comparison

 

AD/Ctl

MCI/Ctl

AD/MCI

Biomarker

p-value

Fold difference

p-value

Fold difference

p-value

Fold difference

MMSE

<0.001

0.63

    

Aβ42

<0.001

0.60

    

CH3L1_290

0.003

1.6

    

Total Tau

0.004

2.0

    

TTHY_56

0.006

1.2

0.04

1.2

  

p-tau181

0.007

2.1

    

A4_117

0.031

0.7

    

CO3_1172

0.031

1.4

    

PTGDS_23

    

0.034

0.82

APOE_301

    

0.049

0.73

  1. p values represent linear regression comparison of log values (corrected by the Benjamini & Hochberg method), adjusting for age and sex, and the table includes all measurements with p < 0.05. Fold difference reflects ratio of the average baseline measurements between groups. Differences for MMSE and ELISA measurements of Aβ42, total tau and p-tau are included for reference (italicized). (AD n = 45, Ctl n = 10, MCI n = 5, aged >60y).
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Molecular Neurodegeneration

ISSN: 1750-1326