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Table 3 Summary of biomarkers that differ at baseline between diagnostic groups

From: Identification of longitudinally dynamic biomarkers in Alzheimer’s disease cerebrospinal fluid by targeted proteomics

  Group comparison
  AD/Ctl MCI/Ctl AD/MCI
Biomarker p-value Fold difference p-value Fold difference p-value Fold difference
MMSE <0.001 0.63     
Aβ42 <0.001 0.60     
CH3L1_290 0.003 1.6     
Total Tau 0.004 2.0     
TTHY_56 0.006 1.2 0.04 1.2   
p-tau181 0.007 2.1     
A4_117 0.031 0.7     
CO3_1172 0.031 1.4     
PTGDS_23      0.034 0.82
APOE_301      0.049 0.73
  1. p values represent linear regression comparison of log values (corrected by the Benjamini & Hochberg method), adjusting for age and sex, and the table includes all measurements with p < 0.05. Fold difference reflects ratio of the average baseline measurements between groups. Differences for MMSE and ELISA measurements of Aβ42, total tau and p-tau are included for reference (italicized). (AD n = 45, Ctl n = 10, MCI n = 5, aged >60y).