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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Motor and cognitive deficits in aged tau knockout mice in two background strains

Figure 2

Complete tau reduction impairs the performance of mice in accelerated Rotarod test at 12 months of age. a) Tau-/- mice significantly maintained less time on the rod. Two-way ANOVA: genotype effects (p = 0.0002) but no genetic background (p = 0.061) effects or interaction (p = 0.519). * p < 0.05, *** p < 0.001, versus age-matched wild type mice (Bonferroni post hoc test). n is indicated in the column of each group. Gender distribution is given in Additional file 6: Table S1. Data are means ± SEM. b-c) No correlation between weight and Rotarod performance in 12-month-old mice (n = 9 – 11). b) Between tau-/- mice in Bl6 background and weight (r2 = 0.003, p = 0.871 by Pearson’s regression). c) Between tau-/- mice in Bl6/129sv background and weight (r2 = 0.043, p = 0.589 by Pearson’s regression).

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