Figure 2From: Motor and cognitive deficits in aged tau knockout mice in two background strainsComplete tau reduction impairs the performance of mice in accelerated Rotarod test at 12 months of age. a) Tau-/- mice significantly maintained less time on the rod. Two-way ANOVA: genotype effects (p = 0.0002) but no genetic background (p = 0.061) effects or interaction (p = 0.519). * p < 0.05, *** p < 0.001, versus age-matched wild type mice (Bonferroni post hoc test). n is indicated in the column of each group. Gender distribution is given in Additional file 6: Table S1. Data are means ± SEM. b-c) No correlation between weight and Rotarod performance in 12-month-old mice (n = 9 – 11). b) Between tau-/- mice in Bl6 background and weight (r2 = 0.003, p = 0.871 by Pearson’s regression). c) Between tau-/- mice in Bl6/129sv background and weight (r2 = 0.043, p = 0.589 by Pearson’s regression).Back to article page