Figure 3
From: Motor and cognitive deficits in aged tau knockout mice in two background strains
Complete tau reduction impairs the performance of mice in Pole test at 12 months of age. a) Tau-/- mice took significantly longer time to turn on the pole. Two-way ANOVA: genotype effects (p < 0.0001) but no genetic background (p = 0.255) effects or interaction (p = 0.352). b) Tau-/- mice took significantly longer time to descend the pole. Two-way ANOVA: genotype effects (p = 0.001) but no genetic background (p = 0.377) effects or interaction (p = 0.903). * p < 0.05, ** p < 0.01, *** p < 0.001, versus age-matched wild type mice (Bonferroni post hoc test). n is indicated in the column of each group. Gender distribution is given in Additional file 6: Table S1. Data are means ± SEM.