Figure 4
From: Motor and cognitive deficits in aged tau knockout mice in two background strains
Complete tau reduction impairs the performance of mice in Openfield test at 12 months of age. a) Tau-/- mice averagely moved significantly less distance per movement. Two-way ANOVA: genotype (p = 0.0002) and genetic background (p < 0.0001) effects but no interaction (p = 0.725). b) Velocity. Two-way ANOVA: genetic background effects (p = 0.0003), but no genotype effects (p = 0.651) or interaction (p = 0.082). c) Time of movement. Two-way ANOVA: genotype (p < 0.0001) and genetic background (p < 0.0001) effects, but no interaction (p = 0.121). d) Distance of locomotion. Two-way ANOVA: genotype (p < 0.0001) and genetic background (p < 0.0001) effects, but no interaction (p = 0.064). *p < 0.05, ** p < 0.01, *** p < 0.001, versus age-matched wild type mice (Bonferroni post hoc test). n is indicated in the column of each group. Gender distribution is given in Additional file 6: Table S1. Data are means ± SEM.