Figure 5
From: Motor and cognitive deficits in aged tau knockout mice in two background strains
Altered hindlimb clasping behavior in tau-/-mice at 12 months of age. a-b) Example of lack of hindlimb clasping (hindlimbs splayed outwards away from abdomen, Scored 0, a; and hindlimb clasping behavior towards the abdomen, Scored 3, b). c) Tau-/- mice exhibited significantly increased hindlimb clasp severity compared to its background control. Two-way ANOVA: genotype effects (p < 0.0001) but no genetic background (p = 0.115) effects or interaction (p = 0.556). **p < 0.01, ***p < 0.001, versus age-matched wild type mice (Bonferroni post hoc test). n is indicated in the column of each group. Gender distribution is given in Additional file 6: Table S1. Data are means ± SEM.