Figure 7
From: Motor and cognitive deficits in aged tau knockout mice in two background strains
Motor deficits are related to nigral degeneration. a-d) Single dose of L-DOPA (10 mg/kg, gavage) rescued motor impairment in 12-month-old tau-/- mice. a) Pole test for Bl6 background mice (time to turn). Two-way ANOVA: genotype effects (p = 0.0001) and interaction (p = 0.008), but no treatment effects (p = 0.142). b) Pole test for Bl6/129sv background mice (time to turn). Two-way ANOVA: genotype (p = 0.032) and treatment (p = 0.002) effects, with interaction (p = 0.009). c) Rotarod test for Bl6 background mice (latency to fall). Two-way ANOVA: genotype effects (p = 0.009) and interaction (p = 0.041), but no treatment effects (p = 0.398). d) Rotarod test for Bl6/129sv background mice (latency to fall). Two-way ANOVA: genotype effects (p = 0.032) and interaction (p = 0.047), but no treatment effects (p = 0.698). *p < 0.05, **p < 0.01, ***p < 0.001, versus age-matched wild type mice (Bonferroni post hoc test). # < 0.05, ## p < 0.01, versus sham-treated tau-/- mice (Bonferroni post hoc test). e) 12-month-old tau-/- mice showed reduced TH-positive nigral neuron number. Two-way ANOVA: genotype effects (p = 0.001), but no genetic background (p = 0.729) effects or interaction (p = 0.799). * p < 0.05, **p < 0.01, versus age-matched wild type mice (Bonferroni post hoc test). n is indicated in the column of each group. Gender distribution is given in Additional file 6: Table S1. Data are means ± SEM.