Figure 5
From: An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALMisoform
Evaluation of PICALM isoform AEI with respect to rs3851179. The indicated PICALM isoforms were analyzed for AEI as a function of rs3851179 (a-c) or rs588076 (d). Each allelic ratio was normalized to the sample’s gDNA ratio. a) The full length PICALM isoform contained exons 18–19 and showed equal allelic ratios, with a non-significant trend towards an increase in the G allele. b) D18-PICALM showed equal allelic ratios and c) D18-19 PICALM showed significant unequal allelic ratios in 9 samples (*p < 0.05), d) The D18-19 PICALM AEI was associated with rs588076 heterozygosity. This pattern of significant AEI was not associated with sex, age or AD status (p > 0.05).