Metabolic pathways associated to gene dysregulation in 5XFAD cortex and hippocampus at M4, M6 and M9: common versus age-specific processes. Biological functions and metabolic pathways associated to gene expression dysregulation were identified using Ingenuity Pathway Analysis (IPA). (A) Data from both the cortex and hippocampus were analyzed as one dataset and the main metabolic pathways affected were clustered according to age (M4, blue; M6, yellow; M9, red). The metabolic pathways affected across all three ages are represented in white and are related to inflammatory and immune responses. (B) The main metabolic pathway affected at M4, M6 and M9 relates to infectious disease, cellular function and antigen presentation.