The transcription factor X-box binding protein-1 in neurodegenerative diseases

Table 1 Evidences of XBP-1 implication in multiple pathologies

Pathologies	Evidence	References
Metabolic disorders
- Diabetes	XBP-1 influences glucose homeostasis	[22–24]
- Non-alcoholic fatty liver disease	XBP-1/PDI/MTP axis activation	[25]
- Non-alcoholic fatty liver disease	TLR4 dependent XBP-1 activation by HFHC diet	[26]
Inflammatory diseases
- Rheumatoid arthritis	XBP-1 upregulation	[27]
- Inflammatory bowel disease	XBP-1 gene single-nucleotide polymorphisms	[28]
Cancers
- Lymphoid malignancies	XBP-1 inhibition reduces leukemic progression	[29]
- Breast cancers	Activation of UPR and upregulation of XBP-1	[30–32]
- Colorectal cancers	XBP-1 overexpression in adenomas and adenocarcinomas	[33]
Neurodegenerative diseases
- Huntington’s disease	XBP-1 invalidation protects over HD	[34]
- Alzheimer’s disease	XBP-1 overexpression in AD patients	[35–37]
- Alzheimer’s disease	XBP-1 polymorphism associated to AD risk	[38]
- Parkinson’s disease	Implication of IRE1-XBP-1 in dopaminergic neurons survival	[39–41]
- Amyotrophic lateral sclerosis	Increase in XBP-1 splicing in ALS models	[42, 43]

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