Changes in the relative abundances of gut bacteria by HFD or exercise. (A) HFD caused a bloom of OTU115 from the genus Streptococcus that returned to nearly undetectable levels in HFD + exercise mice. Bacterial of phyla Firmicutes (B), Bacteroidetes (C), and Tenericutes (D) of the gut microbiome were significantly altered by both HFD and exercise. Data was analyzed by two-way ANOVA with post-hoc Holm-Sidak t-tests with significance indicated as *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. All data presented as mean +/- SEM from n=10/group.