Several bacteria specifically associate with cognitive measures. (A-D) The relative abundance of OTU’s 39 and 82 negatively correlated with % time freezing in the contextual fear conditioning test (A, B) while OTU79 and 57 positively correlated with % time freezing (C, D). Most likely family or genus shown on graph. Color scheme of data points follows the format as in Figure 1 (ND = blue, ND + exercise = green, HFD = red, and HFD + exercise in orange). Linear regression analysis for individual mice was performed with R2 values indicating goodness of fit and uncorrected p values (indicated on graph) for slope calculated by F test.