Figure 10

Diffusion tensor imaging (DTI) of TBI. Diffusion weighted volumes in 64 directions were collected from 22 patients with TBI (18 moderate/severe and 4 mild based upon Mayo classification system for TBI severity) and from 21 age-matched controls. Processing for DTI was performed and anatomic regions-of-interest were identified in controls for performing probabilistic tractography to study thalamo-cortical connections. Templates were generated that included white matter tracts isolated from probabilistic tractography. All brains were transformed into standard space and templates were applied to TBI patients and healthy controls to explore differences in white matter integrity between groups. Patients with a small (A) and large (B) number of abnormal voxels are shown. Histograms of MD values (C) from the patient shown in frame A (blue), frame B (red), as compared with a mean atlas (D) are shown. Images and data are reproduced from Squarcina et al.[116] with permission.