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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Chronic traumatic encephalopathy: clinical‐biomarker correlations and current concepts in pathogenesis

Figure 3

Micrographs from the index case of CTE in an American football player. Panel A, β‐amyloid immunostain of the neocortex (original magnification, ×200) showing frequent diffuse amyloid plaques. Panel B, tau immunostain of the neocortex (original magnification, ×200) showing sparse NFTs and many tau-positive neuritic threads. Panel C, tau immunostain (original magnification, ×400) showing an NFT in a neocortical neuron with extending tau-positive dendritic processes. Panel D, β-amyloid immunostain (original magnification, ×100) of the Sommer’s sector (CA-1 region of the hippocampus) showing no diffuse amyloid plaques. From Omalu et al.[10] with permission.

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