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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Chronic traumatic encephalopathy: clinical‐biomarker correlations and current concepts in pathogenesis

Figure 5

[18 F] T807 autoradiography on brain sections and its comparison with paired helical filament (PHF)-tau and amyloid beta (Aβ) double immunohistochemistry (IHC). (A) Representative images for [18 F] T807 autoradiographs from groups A, B, and C of brains ([18 F] T807 autoradiography, 20 μCi/section). Positive autoradiography signals were observed only in the gray matter of brain from the PHF tau rich group A. Arrows indicate gray matter. (B) [18 F] T807 colocalized with PHF-tau but not with Aβ plaques. (B, top row) Low magnification. (B, bottom row) High magnification from the framed areas. Images of PHF tau (left) and Aβ (right) IHC double immunostaining and autoradiogram image (middle) from two adjacent sections (10 μm) from a PHF-tau rich group A brain (frontal lobe). Positive [18 F] T807 labeling colocalized with immunostaining of PHF tau but not with Aβ plaques, as indicated by arrows. Fluorescent and autoradiographic images were obtained using a Fuji Film FLA-7000 imaging instrument. Scale bars = 2 mm. From Xia et al.[19] with permission.

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